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Phone : +33 561285525
Key words
Experimental evolution, adaptive potential, fitness measure, genomic polymorphisms, transcriptomic variation, bacterial plant pathogen, Raltonia solanacearum, pathogen effectors
Firstname name
DR1 CNRS, Head of RAP team
RESEARCH SUBJECTS
Ralstonia solanacearum pathogenicity and adaptation to plants.
TRAINING
-
1993 PhD from the Paris XI-Orsay University
-
1993-1995 Post-doctoral Fellow at the Department of Genetics at the University of Munich investigating Ustilago maydis filamentous growth, under the direction of Prof. Regine Kahmann.
SCIENTIFIC PRODUCTION
Orcid: 0000-0003-2498-2400
Phone
Tel +33(0)561285592
Key words
Firstname name
Function
RAP team
RESEARCH SUBJECTS
Research topics
TRAINING
Recent funding
RECENT FUNDING
Recent funding
COLLABORATIONS
Collaborations
COMMITTEE MEMBER
Committee member
SCIENTIFIC PRODUCTION
Scientific productions
CONNECTIONS
Science & Society
SCIENCE AND SOCIETY
Science & Society
Phone
+33 (0)5 61 28 55 18
Key words
Bacterial adaptation, experimental evolution, adaptative mutation, genomic, transcriptomic, bacterial epigenetic, DNA methylation, plant pathogen bacteria, Ralstonia solanacearum
Firstname name
Researcher
RAP team
RESEARCH SUBJECTS
I am studying the molecular bases of adaptation to the host plant in the plant pathogen Ralstonia solanacearum using an experimental evolution approach. For that purpose, the GMI1000 strain was evolved by serial passage experiments on a fixed plant line during more than 300 generations. This experiment was conducted on 5 different plant species, and 5 evolved bacterial lineages per plant were generated. I am analyzing both genetic and epigenetic modifications involved in adaptive processes.
TRAINING
2019 HDR (Habilitation à Diriger les Recherches) at Toulouse 3 University
2008-2010 Post-doctoral Fellow at LIPME, Toulouse, on experimental evolution of Ralstonia solanacearum
2004-2008 Post-doctoral Fellow at CIRAD La Réunion, on comparative genomic in Ralstonia solanacearum
2001-2004 Post-doctoral Fellow at Uppsala University, Sweden, on population dynamics in the fungi Daldinia loculata and Lactarius mammosus
1997-2000 Thesis in LEM, Lyon 1 University, on populations of the ectomycorrhizal fungus Hebeloma cylindrosporum
1997 DEA Microbial Ecology at Lyon 1 University
RECENT FUNDING
2017-2023 Role of Epigenetic Modifications in a Plant Pathogen (ANR PRC)
2017 Epigenetic modifications during host adaptation to resistant tomato (FRAIB - LabEx TULIP)
2016-2017 Discrimination of bacterial population by their DNA‐methylation pattern (INRA SPE)
2015-2016 Role of the transcription regulator, efpR, in Ralstonia solanacearum (INRA SPE)
COLLABORATIONS
-Delphine Capela and Philippe Remigi, LIPME, Toulouse
-Yann Pécrix and Stéphane Poussier, UMR PVBMT, CIRAD, Saint-Pierre, La Réunion
-Julien Brillard and Alain Givaudan, DGIMI, Montpellier, France
-Pédro Oliveira, Genoscope, Evry, France
COMMITTEE MEMBER
2020-2024 Management of the Organizing Committee for the National Congress « Rencontres Plantes Bactéries », Aussois, 24 - 28 January 2022 / 28 January - 2 February 2024
2020-2024 Member of the Educational Council of TULIP LabEx, Toulouse
2015-2020 Member of the Scientific Council of TULIP LabEx, Toulouse
2016 Co-head of Organizing Committee for the International Congress
«International Bacterial Wilt Symposium », Toulouse, 3-7 juillet 2016.
SCIENTIFIC PRODUCTION
My publications via ORCID (0000-0001-5282-4157)
Gopalan-Nair R, Jardinaud M-F, Legrand L, Landry D, Barlet X, Lopez-Roques C, Vandecasteele C, Bouchez O, Genin S, Guidot A. (2020) Convergent Rewiring of the Virulence Regulatory Network Promotes Adaptation of Ralstonia solanacearum on Resistant Tomato. Molecular Biology and Evolution [Internet]. Available from: https://doi.org/10.1093/molbev/msaa320
Perrier A, Barlet X, Rengel D, Prior P, Poussier S, Genin S, Guidot A (2019) Spontaneous mutations in a regulatory gene induce phenotypic heterogeneity and adaptation of Ralstonia solanacearum to changing environments. Environmental Microbiology, 21:3140-3152.
Guidot A (2019) Comment un pathogène bactérien change d’hôte ? In : 101 Secrets du Vivant, CNRS Editions.
Perrier A, Barlet X, Peyraud R, Rengel D, Guidot A, Genin S (2018) Comparative transcriptomic studies identify specific expression patterns of virulence factors under the control of the master regulator PhcA in the Ralstonia solanacearum species complex. Microbial Pathogenesis, 116:273-278.
Morel A, Peeters N, Vailleau F, Barberis P, Jiang G, Berthomé R, Guidot A (2018) Plant pathogenicity phenotyping of Ralstonia solanacearum strains. Methods in Molecular Biology, 1734:223-239.
Erill I, Puigvert M, Legrand L, Guarischi-Sousa R, Vandecasteele C, Setubal JC, Genin S, Guidot A, Valls M (2017) Comparative analysis of Ralstonia solanacearum methylomes. Frontiers in Plant Science, 8:504. doi: 10.3389/fpls.2017.00504.
Jiang G, Peyraud R, Remigi P, Guidot A, Berthomé R, Ding W, Jousset A, Genin S, Peeters N (2016) The population dynamics of a bacterial pathogen after host re-infection affects the founding population size. bioRxiv, 061408; doi: https://doi.org/10.1101/061408.
Perrier A, Peyraud R, Rengel D, Barlet X, Lucasson E, Gouzy J, Peeters N, Genin S, Guidot A (2016) Enhanced in planta fitness through adaptive mutations in EfpR, a dual regulator of virulence and metabolic functions in the plant pathogen Ralstonia solanacearum. PloS Pathogens, 12(12): e1006044.doi:10.1371/journal.ppat.1006044.
Reboud X, Sicar, D, Bataillon T, Bedhomme S, Dillmann C, Gaba S, Gallet R, Guidot A, Goldringer I, Jasmin JN, Kaltz O, Méry F, Nidelet T, Schneider D, Spor A (2016). Evolution expérimentale. In: Thomas F., Raymond M., Lefevre T., Biologie évolutive (p. 755-790). De Boeck Supérieur Sciences (DBS Sciences). 1000 p.
Pensec F, Lebeau A, Daunay MC, Chiroleu F, Guidot A, Wicker E (2015) Towards the identification of Type III effectors associated with Ralstonia solanacearum virulence on tomato and eggplant. Phytopathology, 105:1529-1544.
Guidot A, Jiang W, Ferdy JB, Thébaud C, Barberis P, Gouzy J, Genin S (2014) Multihost experimental evolution of the pathogen Ralstonia solanacearum unveils genes involved in adaptation to plants. Molecular Biology & Evolution, 31:2913-2928.
Peeters N, Guidot A, Vailleau F, Valls M (2013) Ralstonia solanacearum, a widespread bacterial plant pathogen in the post-genomic era. Molecular Plant Pathology, 14, 651-662.
Remigi P, Anisimova M, Guidot A, Genin S, Peeters N (2011) Functional diversification of the GALA type III effector family contributes to Ralstonia solanacearum adaptation on different plant hosts. New Phytologist, 192, 976–987.
Coupat-Goutaland B, Bernillon D, Guidot A, Prior P, Nesme X, Bertolla F (2011) Ralstonia solanacearum virulence increased following large interstrain gene transfers by natural transformation. Molecular Plant Microbe Interaction, 24, 497-505.
Macho* AP, Guidot A*, Barberis P, Beuzón CR, Genin S (2010) A competitive index assay identifies several Ralstonia solanacearum Type III effector mutant strains with reduced fitness in host plants. Molecular Plant Microbe Interaction, 23, 1197-1205. *Both authors contributed equally to this work
Remenant B, Coupat-Goutaland B*, Guidot A*, Cellier G, Wicker E, Allen C, Fegan M, Pruvost O, Elbaz M, Calteau A, Salvignol G, Mornico D, Mangenot S, Barbe V, Medigue C, Prior P (2010) Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence. : three original genome sequences for new insights of the species complex. BMC Genomics, 11, 379-395. *Both authors contributed equally to this work
Guidot A, Elbaz M, Carrère S, Siri MI, Pianzzola MJ, Prior P, Boucher C (2009) Specific genes from the potato brown rot strains of Ralstonia solanacearum and their potential use for strain detection. Phytopathology, 99, 1105-1112.
Guidot A, Coupat B, Fall S, Prior P, Bertolla F (2009) Horizontal gene transfer between Ralstonia solanacearum strains detected by comparative genomic hybridization on microarrays. The ISME Journal, 3:549-562.
Högberg N, Guidot A, Jonsson M, Dahlberg A (2009) Microsatellite markers for the ectomycorrhizal basidiomycete Lactarius mammosus. Molecular Ecology Resources, 9:1008-1010.
Guidot A, Prior P, Schoenfeld J, Carrère S, Genin S, Boucher C (2007) Genomic structure and phylogeny of the plant pathogen Ralstonia solanacearum inferred from gene distribution analysis. Journal of Bacteriology, 189:377-387.
Guidot A, Verner MC, Debaud JC, Marmeisse R (2005) Intraspecific variation in use of different organic nitrogen sources by the ectomycorrhizal fungus Hebeloma cylindrosporum. Mycorrhiza, 15:67-177.
Marmeisse R, Guidot A, Gay G, Lambilliotte R, Sentenac H, Combier JP, Melayah D, Fraissinet-Tachet L, Debaud JC (2004) Hebeloma cylindrosporum - a model species to study ectomycorrhizal symbiosis from gene to ecosystem. New Phytologist, 163:481-498.
Guidot A, Johannesson H, Dahlberg A, Stenlid J (2003) Parental tracking in the postfire wood decay ascomycete Daldinia loculata using highly variable nuclear gene loci. Molecular Ecology, 12:1717-1730.
Guidot A, Debaud JC, Marmeisse R (2002) Spatial distribution of the below-ground mycelia of an ectomycorrhizal fungus inferred from specific quantification of its DNA in soil samples. FEMS Microbiology Ecology, 42:477-486.
Guidot A, Debaud JC, Effosse A, Marmeisse R (2004) Below-ground distribution and persistence of an ectomycorrhizal fungus. New Phytologist, 161:539-547.
Guidot A, Debaud JC, Marmeisse R (2003) Nouvelles approches pour l’étude des populations de champignons ectomycorhiziens: typage génétique des mycorhizes et analyse de l’ADN du sol. Les Actes du BRG, 4, 479-489.
Guidot A, Gryta H, Gourbière F, Debaud JC, Marmeisse R (2002) Forest habitat characteristics affect balance between sexual reproduction and clonal propagation of the ectomycorrhizal mushroom Hebeloma cylindrosporum. Oikos, 99:25-36.
Guidot A, Debaud JC, Marmeisse R (2001) Correspondence between genet diversity and spatial distribution of above- and below-ground populations of the ectomycorrhizal fungus Hebeloma cylindrosporum. Molecular Ecology, 10:1121-1131.
Guidot A, Lumini E, Debaud JC, Marmeisse R (1999) The nuclear ribosomal DNA intergenic spacer as a target sequence to study intraspecific diversity of the ectomycorrhizal basidiomycete Hebeloma cylindrosporum directly on Pinus root systems. Applied and Environmental Microbiology, 65:903-909.
Phone : 335 61 28 55 25
Key words
Systems biology, mathematical modeling, metabolic modeling, metabolism, trophism, tomato plant, Ralstonia solanacearum, Xylella fastidiosa
Firstname name
Researcher INRAE
Team : RAP
RESEARCH SUBJECTS
I study the link between metabolism and virulence. To this end, I used systems biology and in particular metabolic modelling. I also started the modelling of the infection’s dynamics of plant pathogens. My work time is split between modelling and experimentations to calibrate my models.
TRAINING
2014 – 2016 : Postdoctorate at the Physiology and Biotechnology of Algae laboratory (IFREMER), including 6 months as a visiting scientist at Imperial College of London (dtp Chemical engineering)
2011 – 2014 : PhD INRAE - Inria at the Laboratory of Environmental Biotechnology at INRAE Narbonne and in the team BIOCORE of Inria Sophia-Antipolis.
2010 – 2011 : Bioinformatician, Mount Sinai School of Medicine (New York)
2009 - 2010 : MSc Computing for Biomedical Applications, Imperial College of London.
2007 - 2010 : Ecole Centrale de Lyon (general engineering degree).
2005 – 2007 : Training classes in mathematics, physics and computing (MPSI, MP*)
RECENT FUNDING
Recent funding
COLLABORATIONS
Collaborations
COMMITTEE MEMBER
Elected member of the scientific council of SPE dpt.
Elected member of the scientific council of TULIP LABEX.
Elected member of the laboratory council.
SCIENTIFIC PRODUCTION
My authored publications via ORCID.
HOBBIES
On a non-professional level, one of my favorite hobby is to hold a blog on cooking and pastry.
Firstname name
Function
Team
RESEARCH SUBJECTS
Research topics
TRAINING
Recent funding
Phone
Recent funding
Key words
RECENT FUNDING
COLLABORATIONS
Collaborations
EDUCATION
Teachings
COMMITTEE MEMBER
Committee member
SCIENTIFIC PRODUCTION
Scientific productions
CONNECTIONS
Science & Society
SCIENCE AND SOCIETY
Science & Society
OTHER AFFILIATION
Other affiliations
Firstname name
Function
Team
RESEARCH SUBJECTS
Research topics
TRAINING
Recent funding
Phone
Key words
SCIENTIFIC PRODUCTION
Scientific productions
Phone
+33 5 61 28 50 45
Key words
System biology, metabolic modeling, plant pathogens, tomato, xylem, Xylella fastidiosa, Ralstonia solanacearum, metabolic networks
Léo GERLIN
Function
PhD student UPS / ED SEVAB (2023 - 2026)
RESEARCH SUBJECTS
Spatio-temporal study of bacterial population dynamic to decypher barriers of host plants to an infection by Ralstonia solanacearum
TRAINING
INSA Toulouse – Biological Engineering (MSc)
SCIENTIFIC PRODUCTION
2020 : Master Microbiologie Moléculaire de l’UT3 de Toulouse.
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Phone
+33 5 61 28 50 45
Key words
System biology, metabolic modeling, plant pathogens, tomato, xylem, Xylella fastidiosa, Ralstonia solanacearum, metabolic networks
Léo GERLIN
Function
PhD student UPS / ED SEVAB (2023 - 2026)
RESEARCH SUBJECTS
Spatio-temporal study of bacterial population dynamic to decypher barriers of host plants to an infection by Ralstonia solanacearum
TRAINING
INSA Toulouse – Biological Engineering (MSc)
EDUCATION
- Practical Courses - Solution Chemistry - INSA Toulouse 1ère année (2018 - 2020)
- Lecture and Practical Courses - Metabolic networks and modeling – Université Paul Sabatier – MSc Bioinformatics and Systems Biology (2018 - 2020)
SCIENTIFIC PRODUCTION